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Diagnosis and Classification of Amyloidosis



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Slide 4

December 2009

This is a duodenal biopsy specimen showing subtle amyloid deposition in the basal lamina of duodenal glands. In the upper left panel, Congo red stain gives pale orange-red reactivity with the amyloid deposits. In the upper right panel, under polarized light the deposits show characteristic apple-green birefringence. Similarly immunohistochemistry for serum amyloid P component (SAP) labels the amyloid deposited in the basal lamina of the glands. By electron microscopy (EM), the amyloid is composed of nonbranching fibrils.

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