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Diagnosis and Classification of Amyloidosis



Summary: Diagnosis

Slide 29

December 2009

In summary, Congo red histochemical stain is the gold standard for diagnosis of amyloidosis. It is important to ensure that Congo red staining performed in the laboratory is sensitive and specific by using a number of appropriate positive and negative controls. The pathologist should have a low threshold for requesting a Congo red staining as early diagnosis and treatment are important for preventing irreversible organ damage. However, the pathologist should have a high threshold for a positive call on Congo red stain to prevent unnecessary further clinical interventions without a firm diagnosis of amyloidosis.

Summary: Diagnosis

 


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