Diagnosis and Classification of Amyloidosis

Diagnosis

December 2009

Therefore, the patient was diagnosed to have renal amyloidosis, AL-lambda type. Additional clinical investigations showed the presence of an IgG/lambda monoclonal protein and a small population of IgG/lambda restricted plasma cells in the bone marrow. The patient was treated for the underlying plasma cell proliferative disorder to stop progression of amyloidosis.

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Diagnosis

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Jump to section:

• Introduction
• Amyloidosis
• Diagnosis¹
• Slide Images
• Subtypes: Historical Context
• Subtypes²
• Subtyping
• Subtyping
• Subtyping in Tissues
• Mass Spectrometry-Based Proteomic Analysis of Amyloidosis
• Protein Extraction
• Fragmented Peptides
• Mass/charge of Daughter Ions Measured
• Bioinformatics
• Case History 1
• Bone Marrow Biopsy Image
• Flow Cytometry Immunophenotyping
• Bone Marrow Image
• Congo Red-Positive Slide Image
• Immunohistochemistry Slide Images
• Microdissection
• MS-Based Proteomic Analysis
• Diagnosis
• Case History 2
• Renal Biopsy Image
• MS-Based Proteomic Analysis
• Diagnosis
• Mass Spectrometry Results in 50 Cases of Amyloidosis³
• Summary: Diagnosis
• Summary: Classification
• References
• Questions?