Diagnosis and Classification of Amyloidosis

Immunohistochemistry Slide Images

December 2009

Immunohistochemistry performed for typing amyloid was equivocal and showed that the deposits were positive for SAP, TTR and immunoglobulin lambda light chain but appeared negative for SAA and immunoglobulin kappa light chain.

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• Introduction
• Amyloidosis
• Diagnosis¹
• Slide Images
• Subtypes: Historical Context
• Subtypes²
• Subtyping
• Subtyping
• Subtyping in Tissues
• Mass Spectrometry-Based Proteomic Analysis of Amyloidosis
• Protein Extraction
• Fragmented Peptides
• Mass/charge of Daughter Ions Measured
• Bioinformatics
• Case History 1
• Bone Marrow Biopsy Image
• Flow Cytometry Immunophenotyping
• Bone Marrow Image
• Congo Red-Positive Slide Image
• Immunohistochemistry Slide Images
• Microdissection
• MS-Based Proteomic Analysis
• Diagnosis
• Case History 2
• Renal Biopsy Image
• MS-Based Proteomic Analysis
• Diagnosis
• Mass Spectrometry Results in 50 Cases of Amyloidosis³
• Summary: Diagnosis
• Summary: Classification
• References
• Questions?