Diagnosis and Classification of Amyloidosis
Amyloidosis
December 2009
Amyloidoses are a group of diseases characterized by abnormal extracellular deposition of proteins in a beta-pleated sheet format. The term amyloidosis is derived from “amylum,” starch in Latin. Although molecular pathogenesis of amyloidosis is not known, it is believed that amyloidosis is caused by misfolding of proteins into a structure that cannot be cleared by physiological scavenging mechanisms. Amyloidosis can be localized to a single organ site or can be systemic involving multiple organs. Systemic amyloidosis is, clinically, most important as vital organs such as the heart or the kidneys are frequently affected.
Amyloidosis |
Jump to section:
- Introduction
- Amyloidosis
- Diagnosis1
- Slide Images
- Subtypes: Historical Context
- Subtypes2
- Subtyping
- Subtyping
- Subtyping in Tissues
- Mass Spectrometry-Based Proteomic Analysis of Amyloidosis
- Protein Extraction
- Fragmented Peptides
- Mass/charge of Daughter Ions Measured
- Bioinformatics
- Case History 1
- Bone Marrow Biopsy Image
- Flow Cytometry Immunophenotyping
- Bone Marrow Image
- Congo Red-Positive Slide Image
- Immunohistochemistry Slide Images
- Microdissection
- MS-Based Proteomic Analysis
- Diagnosis
- Case History 2
- Mass Spectrometry Results in 50 Cases of Amyloidosis3
- Summary: Diagnosis
- Summary: Classification
- References
- Questions?
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