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Diagnosis and Classification of Amyloidosis


Slide 2

December 2009

Amyloidoses are a group of diseases characterized by abnormal extracellular deposition of proteins in a beta-pleated sheet format. The term amyloidosis is derived from “amylum,” starch in Latin. Although molecular pathogenesis of amyloidosis is not known, it is believed that amyloidosis is caused by misfolding of proteins into a structure that cannot be cleared by physiological scavenging mechanisms. Amyloidosis can be localized to a single organ site or can be systemic involving multiple organs. Systemic amyloidosis is, clinically, most important as vital organs such as the heart or the kidneys are frequently affected.



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