Diagnosis and Classification of Amyloidosis
Case History 1
December 2009
I will now discuss two cases where mass spectrometry-based proteomic analysis was diagnostic. The first case was a 74-year-old male who presented with a long history of CLL and symptoms and signs such as carpal tunnel syndrome and restrictive cardiomyopathy, suggestive of systemic amyloidosis. In 2009, a bone marrow biopsy was performed and at that point, the patient had elevated lambda free light chain levels.
Case History 1 |
Jump to section:
- Introduction
- Amyloidosis
- Diagnosis1
- Slide Images
- Subtypes: Historical Context
- Subtypes2
- Subtyping
- Subtyping
- Subtyping in Tissues
- Mass Spectrometry-Based Proteomic Analysis of Amyloidosis
- Protein Extraction
- Fragmented Peptides
- Mass/charge of Daughter Ions Measured
- Bioinformatics
- Case History 1
- Bone Marrow Biopsy Image
- Flow Cytometry Immunophenotyping
- Bone Marrow Image
- Congo Red-Positive Slide Image
- Immunohistochemistry Slide Images
- Microdissection
- MS-Based Proteomic Analysis
- Diagnosis
- Case History 2
- Mass Spectrometry Results in 50 Cases of Amyloidosis3
- Summary: Diagnosis
- Summary: Classification
- References
- Questions?
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