Diagnosis and Classification of Amyloidosis

Bioinformatics

December 2009

The resulting fragmentation pattern is correlated to theoretical fragmentation patterns of all possible human tryptic peptide sequences from the Swissprot database using specialized search algorithm, and the amino acid sequence of the parent peptide is predicted.

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Jump to section:

• Introduction
• Amyloidosis
• Diagnosis¹
• Slide Images
• Subtypes: Historical Context
• Subtypes²
• Subtyping
• Subtyping
• Subtyping in Tissues
• Mass Spectrometry-Based Proteomic Analysis of Amyloidosis
• Protein Extraction
• Fragmented Peptides
• Mass/charge of Daughter Ions Measured
• Bioinformatics
• Case History 1
• Bone Marrow Biopsy Image
• Flow Cytometry Immunophenotyping
• Bone Marrow Image
• Congo Red-Positive Slide Image
• Immunohistochemistry Slide Images
• Microdissection
• MS-Based Proteomic Analysis
• Diagnosis
• Case History 2
• Renal Biopsy Image
• MS-Based Proteomic Analysis
• Diagnosis
• Mass Spectrometry Results in 50 Cases of Amyloidosis³
• Summary: Diagnosis
• Summary: Classification
• References
• Questions?