Monitoring Monoclonal Gammopathies
Serum Protein Electrophoresis and Immunofixation Electrophoresis
November 2009
On this next slide is an example of a measurable serum M-spike. The upper portion of the figure is a serum protein electrophoresis and immunofixation electrophoresis of serum from a normal donor. The lower portion is from a patient with multiple myeloma. You can see that this patient has a monoclonal IgG kappa protein from the IFE or immunofixation electrophoresis gel and that the PEL or protein electrophoresis scan quantitates the M-spike as 3.8 g/dL.
Electrophoresis |
Jump to section:
- Introduction
- Slide Images
- International Myeloma Working Group: Disease Monitoring
- Serum Protein Electrophoresis and Immunofixation Electrophoresis
- Serum and Urine Protein Electrophoresis and Immunofixation Electrophoresis
- Methods for Monitoring Monoclonal Gammopathies: 2005 IMWG
- Methods for Monitoring Monoclonal Gammopathies
- Small IgG kappa M-spike
- Large IgG kappa M-spike
- Relationship of Serum Agarose Electrophoresis M-spike and Ig Quantitation1
- Disease Monitoring
- Monoclonal Gammopathies: Primary Systemic Amyloidosis
- Free Light Chain: Antibody Specificity
- FLC κ/λ Ratio: Disease Sensitivity2
- Methods for Monitoring Monoclonal Gammopathies
- International Myeloma Working Group: 2009 Guidelines for Disease Monitoring3
- Response Criteria for FLC4,5
- Receiver Operator Curve (ROC): % FLC Reduction vs. Overall Hematologic Response6
- International Myeloma Working Group: 2009 Guidelines for Disease Monitoring
- References
- Questions?
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