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Monitoring Monoclonal Gammopathies

International Myeloma Working Group: 2009 Guidelines for Disease Monitoring 3

Slide 19

November 2009

In summary, the current guidelines for disease monitoring suggest: use serum and urine electrophoresis if there are measurable M-spikes, that is, >1g/dL in serum and >200 mg/24 hour in urine. And, if you use quantitive serum Ig for large M-spikes, remember that they should correlate with the M-spikes, but are not equivalent. In addition, if there is no measurable M-spike in serum or urine, use the serum free light chain quantitation if the free light chain ratio is abnormal and the monoclonal free light chain is >10 mg/dL.

2009 Guidelines


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