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Monitoring Monoclonal Gammopathies



Response Criteria for FLC 4,5

Slide 17

November 2009

The response criteria for a measurable, monoclonal serum free light chain is similar to the criteria for the serum M-spike. A 50% reduction in the free light chain concentration is considered a partial response, and a complete response is normalization of the free light chain ratio, plus normal immunofixation and normal bone marrow. The 50% reduction was chosen by analogy to the serum M-spike. We’ve recently analyzed an Eastern Cooperative Oncology Group study for the use of serum free light chain to predict hematologic response.

Response Criteria

 


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