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PSA Standardization



Effect on "Watchful Waiting"

Slide 29

October 2009

Visually we can see this difference again in the figure shown.  After some amount of time a man’s PSA becomes elevated or greater than the 4.0 ng/mL cutoff with a Hybritech assay. Using that same cutoff in a WHO standardized assay, the PSA is now less than 4.0 ng/mL or may be considered “normal”.  After some period of time, perhaps an abnormal result would be obtained but if the increase in PSA is due to cancer there is a greater risk in increasing the stage and grade of prostate cancer with the watchful waiting approach.

Watchful Waiting

 


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