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PSA Standardization

Fixed Thresholds Produce Problems for Biopsy Recommendations

Slide 28

October 2009

A recent study in Clinical Chemistry reported the results of an ‘in-silico’ (or computer modeled) study where 106 samples were used to establish the bias between Hybritech and WHO calibrations.  Data from 5865 tests were then compared for biopsy recommendation and cancer detection.  In remarkable agreement with the analysis of the previous studies this study found a 19% decrease in the biopsy recommendation rate. These studies demonstrate the ~20% lower results from a WHO calibration result in missed opportunities for follow-up care for men who may be at risk for prostate cancer.  Clearly use of a fixed threshold can produce problems for further referrals for biopsy.

Fixed Thresholds


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