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PSA Standardization



WHO Calibration/Concordance at 4.0 ng/mL Cutoff5

Slide 25

October 2009

However, if we were to use the same 4.0 cutoff for a Hybritech calibrated and a WHO standardized assay then we would not miss diagnosing any men with prostate cancer but we would have 38 men (or 18%) who would be considered positive on the Hybritech assay but below the 4.0 cutoff with a WHO standardized assay. This signifies those 38 men would not have received follow-up if the same cutoff was used and suggests manufacturers who offer WHO standardized assays need to provide assay-specific cutoffs that logically would not be 4.0 ng/mL, but some concentration below 4.0.

WHO Calibration

 


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