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PSA Standardization



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Analytical Differences15

Slide 20

October 2009

A study published in Clinical Chemistry in 2006 elegantly demonstrates that an increase of total PSA of 0.5 or 0.75 ng/mL/year, which are values used in the calculation of PSA velocity, can be the result simply of a change in the assay system used rather than an actual change in PSA concentrations.  Comparing five different immunoassays for total PSA produced variable results in that study, and all assays agreed within 15% of one another. However, some manufacturers, even though technically traceable to the WHO standard, produced patient results that mirrored the Hybritech assay results, which can be confusing and misleading.

Analytical Differences

 


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