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PSA Standardization

Optimizing Clinical Sensitivity and Specificity: Age/Ethnic Reference Intervals9,10

Slide 12

October 2009

Use of age and ethnic specific reference intervals was also suggested to improve the specificity and sensitivity of PSA.  Many studies have noted that men without prostate cancer will have higher PSA values as they age.  Use of age adjusted cutoffs could improve sensitivity in younger males, allowing their cancer to be detected earlier, and improve specificity in older males so the false-positive rate is reduced and less biopsies are performed.  This approach has not been uniformly accepted and the most recent National Academy of Clinical Biochemistry guidelines in 2008 do not recommend age-specific reference ranges.

Optimizing Sensitivity


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