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PSA Standardization

Increase Specificity Using PSA Velocity8

Slide 11

October 2009

One way to increase the specificity of PSA is to modify how it is interpreted, and evaluate the change in PSA over time (in months or years), termed PSA velocity.  If the patient has metastatic cancer the PSA will change rapidly over time, to a greater extent than if there is localized cancer contained within the prostate or to an even a greater extent compared to a control population or men with BPH.

The National Cancer Comprehensive Network guidelines recommend calculation of PSA velocity over a one year period.  When the total PSA is less than 4, an increase of greater than or equal to 0.35 ng/mL/year is considered suspicious and when the PSA is between 4-10 ng/mL an increase of greater than or equal to 0.75 ng/mL/year is considered suspicious.  Ideally the clinician would use three specimens over an 18 to 24 month period to adequately assess the velocity.

Increase Specificity


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