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Laboratory Diagnosis of HIV Infection



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Principle of Future Combined HIV Antigen-Antibody ELISAs

Slide 5

October 2009

In this slide, I’ve illustrated the chemistry principle of the HIV antigen and antibody combination enzyme immunoassays that are undergoing clinical trials in the United States, but are commercially available in Europe and the rest of the world. You can see in this schematic diagram that both the antigens of HIV-1 and -2, indicated by the blue and purple diamonds, are actually attached in the reaction well and the antibodies for capturing HIV-1 p24 antigen are indicated in blue and those are also attached to the stationary well. So the target that this assay is trying to capture are the p24 antigen represented by the orange diamond and the orange-colored antibodies that are represented as an inverted Y.

Principle of Future

 


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