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The INR and FFP

Is This a Good Relationship with Regard to Transfusion Practice?


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INR, FFP & Bleeding, cont.

Slide 23

December 2008

A significant dose-response effect was not observed. Higher volumes of transfused FFP did not result in larger decreases in the PT post-transfusion. When patients receiving one unit versus two units of FFP were compared with regard to their likelihood of achieving a correction of their PT to at least halfway to normal, there was no significant difference between these two groups.

Also documented was the proportion of patients who achieved at least a 50% correction of their PT/INR, who received not more than one red cell unit, which was 15.9%, versus the proportion who received more than one red cell unit, which was 15.7%. This finding suggests that the effect of FFP on coagulation testing was essentially the same in stable and more actively bleeding pts.

INR, FFP & Bleeding, cont.


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