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The INR and FFP

Is This a Good Relationship with Regard to Transfusion Practice?


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INR, FFP & Bleeding, cont.

Slide 18

December 2008

In a paper published in 2003, Youssef and co-workers conducted a two-part study, one part retrospective and one part prospective to evaluate the effectiveness of FFP in correcting the PT in patients with chronic liver disease.

In the retrospective analysis, a total of 80 patients were included. These patients had a pre-transfusion prolongation of the PT of more than 3 seconds above the control value, and this was despite having received parenteral vitamin K. All patients had evidence of cirrhosis of the liver, either by liver biopsy, or by clinical, biochemical and/or imaging criteria.

Twenty patients with liver disease and a prolonged PT were included in the prospective portion of the study. The indications for FFP transfusions in the prospective portion were: active bleeding, 4 patients; prior an invasive procedure, 11 patients; and concern for spontaneous bleeding, 5 patients.

INR, FFP & Bleeding, cont.


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