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Genetic Testing for Autosomal Dominant Hypercholesterolemia


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Statin Treatment-How Early?

Slide 13

December 2008

While I’m on the topic of treatment for ADH, I’d like to discuss statin treatment in ADH a little further. Statins are the most common drug used to treat ADH and studies have demonstrated that statins should be given as early as possible in the course of ADH. In fact, atherosclerotic disease begins in childhood and is progressive.  50% of children and 85% of young adults have fatty streaks which are the earliest pathological abnormality in atherosclerosis.

In addition, it has been shown that 45% of 22-year-olds have evidence of atherosclerosis. Studies have been performed on the evaluation of statin treatment in children and adolescents and these studies have supported the short-term safety and efficacy of such treatment. However, studies examining the long-term treatment of statin treatment on children are lacking at this time.

Statin Treatment-How Early?


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