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Risk Stratification in Chronic Lymphocytic Leukemia

The Role of the Clinical Laboratory

Blood: Prognostic Indicators

Slide 8

November 2008

In the blood, doubling time (DT) is the length of time it takes to double the white count and has been used as an indirect marker of progression of disease.

I also want to bring up the topic of fragile cells.  We all know that fragile cells are a common finding in a peripheral blood smear of a patient with CLL. The lab techs often consider fragile cells as an irritant to be dealt with. The big question that remains is why do we see fragile cells in some cases, but not in others?

Blood: Prognostic Indicators


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