Risk Stratification in Chronic Lymphocytic Leukemia

Blood: Prognostic Indicators

November 2008

In the blood, doubling time (DT) is the length of time it takes to double the white count and has been used as an indirect marker of progression of disease.

I also want to bring up the topic of fragile cells.  We all know that fragile cells are a common finding in a peripheral blood smear of a patient with CLL. The lab techs often consider fragile cells as an irritant to be dealt with. The big question that remains is why do we see fragile cells in some cases, but not in others?

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Blood: Prognostic Indicators

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• Introduction
• Goals Today
• Risk Assessment
• Risk Assessment in CLL
• CLL Rai Stage: Treatment Free
• CLL: Nodular Pattern of BM Infiltration
• CLL: Pattern of BM Infiltration
• Blood: Prognostic Indicators
• CLL and Fragile Cells
• CLL: Fragile Cells and Time to Treatment
• CLL Prognostics: CD38
• CLL Rai Stage 0: CD38
• ZAP-70 in B-CLL
• ZAP-70 in B-CLL: Detection
• ZAP-70 in B-CLL: Questions
• ZAP-70 by Flow in CLL
• ZAP-70 by Flow in CLL
• ZAP-70 by Flow in CLL
• ZAP-70: Immunohistochemistry
• CLL Rai Stage 0: ZAP-70
• CD49d in CLL
• CD49d: Clinical Role
• Time to Treatment (TTT) & Overall Survival (OS) from Diagnosis*
• CD49d in CLL
• CD49d in CLL
• Immunoglobulin Variable (IgVH) Region Mutation Status
• IgVH Sequencing
• CLL Rai Stage 0: IgVH
• Chromosome Anomalies in Chronic Lymphocytic Leukemia
• Distribution of Chromosome Anomalies in CLL Detected by FISH
• 13q-: A Microdeletion in B-CLL
• Overall Survival: By FISH Anomaly
• Risk Assessment in CLL: Summary
• Risk Assessment In CLL
• Risk Assessment
• Goals Today
• Questions?