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Risk Stratification in Chronic Lymphocytic Leukemia

The Role of the Clinical Laboratory



CLL: Pattern of BM Infiltration

Slide 7

November 2008

On the left hand side of this slide is the nodular and interstitial pattern of bone marrow involvement. On the right hand side is the diffuse pattern of marrow infiltration, defined as having less than 5% of the cellularity as adipose tissue. Several studies have pointed out the association of this diffuse pattern of infiltration, if strictly defined, with more rapid progression of disease. Recent studies, however, are showing that this pattern of infiltration may not be independent of other prognostic risk factors.

Pattern of BM Infiltration

 


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