Risk Stratification in Chronic Lymphocytic Leukemia

Goals Today

November 2008

Our goals today will be to understand the various prognostic risk factors that are used in evaluating chronic lymphocytic leukemia (CLL), to realize how clinicians use prognostic risk factors in the management of patients, and to understand how risk factor analysis is used in conjunction with diagnostic testing in CLL.

Please note that there is a previous Hot Topics on CLL: “Chronic Lymphocytic Leukemia: New Approaches for a Common Disease” That particular Hot Topic dealtwith the diagnostic criteria of CLL and monoclonal B-cell lymphocytosis as well as minimal residual disease detection in patients with CLL.

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Jump to section:

• Introduction
• Goals Today
• Risk Assessment
• Risk Assessment in CLL
• CLL Rai Stage: Treatment Free
• CLL: Nodular Pattern of BM Infiltration
• CLL: Pattern of BM Infiltration
• Blood: Prognostic Indicators
• CLL and Fragile Cells
• CLL: Fragile Cells and Time to Treatment
• CLL Prognostics: CD38
• CLL Rai Stage 0: CD38
• ZAP-70 in B-CLL
• ZAP-70 in B-CLL: Detection
• ZAP-70 in B-CLL: Questions
• ZAP-70 by Flow in CLL
• ZAP-70 by Flow in CLL
• ZAP-70 by Flow in CLL
• ZAP-70: Immunohistochemistry
• CLL Rai Stage 0: ZAP-70
• CD49d in CLL
• CD49d: Clinical Role
• Time to Treatment (TTT) & Overall Survival (OS) from Diagnosis*
• CD49d in CLL
• CD49d in CLL
• Immunoglobulin Variable (IgVH) Region Mutation Status
• IgVH Sequencing
• CLL Rai Stage 0: IgVH
• Chromosome Anomalies in Chronic Lymphocytic Leukemia
• Distribution of Chromosome Anomalies in CLL Detected by FISH
• 13q-: A Microdeletion in B-CLL
• Overall Survival: By FISH Anomaly
• Risk Assessment in CLL: Summary
• Risk Assessment In CLL
• Risk Assessment
• Goals Today
• Questions?