Risk Stratification in Chronic Lymphocytic Leukemia
The Role of the Clinical Laboratory
ZAP-70 in B-CLL: Questions
November 2008
Several questions remain for ZAP-70 in CLL.
When validation studies for ZAP-70 are done, should they be done versus clinical outcome or IgVH status? Clearly clinical outcome is the gold standard to be used.
Do peripheral blood and bone marrow give comparable results? Bone marrow clinically validation studies have not been done, and thus is not the preferred specimen type.
For tissue stains is ZAP-70 fixation-dependent? We don’t know the impact that various fixatives and decalcification may have on ZAP-70. We do know that ZAP-70 is not stable and begins to deteriorate after 48 hours and is temperature dependent. It also must be realized that as of now, ZAP-70 does not appear to have any prognostic role in non-CLL B-cell lymphoproliferative cases.
ZAP-70 in B-CLL: Questions |
Jump to section:
- Introduction
- Goals Today
- Risk Assessment
- Risk Assessment in CLL
- CLL Rai Stage: Treatment Free
- CLL: Nodular Pattern of BM Infiltration
- CLL: Pattern of BM Infiltration
- Blood: Prognostic Indicators
- CLL and Fragile Cells
- CLL: Fragile Cells and Time to Treatment
- CLL Prognostics: CD38
- CLL Rai Stage 0: CD38
- ZAP-70 in B-CLL
- ZAP-70 in B-CLL: Detection
- ZAP-70 in B-CLL: Questions
- ZAP-70 by Flow in CLL
- ZAP-70 by Flow in CLL
- ZAP-70 by Flow in CLL
- ZAP-70: Immunohistochemistry
- CLL Rai Stage 0: ZAP-70
- CD49d in CLL
- CD49d: Clinical Role
- Time to Treatment (TTT) & Overall Survival (OS) from Diagnosis*
- CD49d in CLL
- CD49d in CLL
- Immunoglobulin Variable (IgVH) Region Mutation Status
- IgVH Sequencing
- CLL Rai Stage 0: IgVH
- Chromosome Anomalies in Chronic Lymphocytic Leukemia
- Distribution of Chromosome Anomalies in CLL Detected by FISH
- 13q-: A Microdeletion in B-CLL
- Overall Survival: By FISH Anomaly
- Risk Assessment in CLL: Summary
- Risk Assessment In CLL
- Risk Assessment
- Goals Today
- Questions?
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