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Risk Stratification in Chronic Lymphocytic Leukemia

The Role of the Clinical Laboratory

ZAP-70 in B-CLL

Slide 13

November 2008

ZAP-70 is an intracellular tyrosine kinase marker, normally expressed in T cells and NK cells, but has also been found to be associated as a risk factor marker in CLL. We know that ZAP-70 is involved with the signaling response, activation and proliferation of T-cells in particular.

In CLL, it has been discovered that B-cell receptor signaling is certainly much more efficient in ZAP-70+ cells thus implying an association with activation and proliferation of those B-cells.

 ZAP-70 expression has also been associated with unmutated IgVH status, which is a worse prognostic finding.  ZAP-70 appears to be stable over time regardless of treatment, as opposed to CD38.

ZAP-70 in B-CLL


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