Risk Stratification in Chronic Lymphocytic Leukemia
The Role of the Clinical Laboratory
ZAP-70 in B-CLL
November 2008
ZAP-70 is an intracellular tyrosine kinase marker, normally expressed in T cells and NK cells, but has also been found to be associated as a risk factor marker in CLL. We know that ZAP-70 is involved with the signaling response, activation and proliferation of T-cells in particular.
In CLL, it has been discovered that B-cell receptor signaling is certainly much more efficient in ZAP-70+ cells thus implying an association with activation and proliferation of those B-cells.
ZAP-70 expression has also been associated with unmutated IgVH status, which is a worse prognostic finding. ZAP-70 appears to be stable over time regardless of treatment, as opposed to CD38.
ZAP-70 in B-CLL |
Jump to section:
- Introduction
- Goals Today
- Risk Assessment
- Risk Assessment in CLL
- CLL Rai Stage: Treatment Free
- CLL: Nodular Pattern of BM Infiltration
- CLL: Pattern of BM Infiltration
- Blood: Prognostic Indicators
- CLL and Fragile Cells
- CLL: Fragile Cells and Time to Treatment
- CLL Prognostics: CD38
- CLL Rai Stage 0: CD38
- ZAP-70 in B-CLL
- ZAP-70 in B-CLL: Detection
- ZAP-70 in B-CLL: Questions
- ZAP-70 by Flow in CLL
- ZAP-70 by Flow in CLL
- ZAP-70 by Flow in CLL
- ZAP-70: Immunohistochemistry
- CLL Rai Stage 0: ZAP-70
- CD49d in CLL
- CD49d: Clinical Role
- Time to Treatment (TTT) & Overall Survival (OS) from Diagnosis*
- CD49d in CLL
- CD49d in CLL
- Immunoglobulin Variable (IgVH) Region Mutation Status
- IgVH Sequencing
- CLL Rai Stage 0: IgVH
- Chromosome Anomalies in Chronic Lymphocytic Leukemia
- Distribution of Chromosome Anomalies in CLL Detected by FISH
- 13q-: A Microdeletion in B-CLL
- Overall Survival: By FISH Anomaly
- Risk Assessment in CLL: Summary
- Risk Assessment In CLL
- Risk Assessment
- Goals Today
- Questions?
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