What the FDA Relabeling of Abacavir Means for You and Your Patient

Naming Conventions - HLA-B*5701

November 2008

The naming convention can be confusing. HLA-B is the name of the gene located on chromosome 6. B57 indicates a group of protein antigens with different amino acid substitutions, encoded by the HLA-B alleles, which are detected immunologically.

The asterisk (*) indicates it is nucleic acid - an allele - and not a protein, which is an antigen. The 01 indicates a specific allele with a specific DNA sequence. There are 16 HAL-B*5701 alleles with amino acid changes that have been found at this time. Many of these are rare, for example HLA-B*5708 found in 1 in 25,000 patients.

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Jump to section:

• Introduction
• Highly Active Antiretroviral Therapy
• Abacavir
• FDA Caution and Relabeling
• Abacavir Hypersensitivity
• Abacavir HSR and HLA Gene
• HLA-B Antigens and Alleles
• Naming Conventions - HLA-B*5701
• Chromosome 6
• Detecting HLA Alleles
• HLA-B*5701 Correlations
• HLA-B*5701 Correlations
• Clinical Utility³
• Problems
• If HSR Symptoms are Present⁴
• If HSR Symptoms are Present⁴
• Recommendations for Physicians⁵
• Recommendations for Physicians⁵
• Information for Patients⁵
• Information for Patients⁵
• HLA-B*5701 Genotyping
• References
• Questions?