What the FDA Relabeling of Abacavir Means for You and Your Patient

HLA-B Antigens and Alleles

November 2008

The Class I HLA proteins (including HLA-B) present peptides to CD8+ T lymphocytes. This may elicit an immune response. HLA-B is a single gene, but generates many protein antigens. However, more than 500 allelic variants are identified by molecular methods. Not all these allelic variants cause a change in the amino acid sequence of the HLA-B antigen, and approximately 50 HLA-B protein antigens encoded by the HLA-B allelic variants and these are identified serologically.

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HLA-B Antigens and Alleles

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Jump to section:

• Introduction
• Highly Active Antiretroviral Therapy
• Abacavir
• FDA Caution and Relabeling
• Abacavir Hypersensitivity
• Abacavir HSR and HLA Gene
• HLA-B Antigens and Alleles
• Naming Conventions - HLA-B*5701
• Chromosome 6
• Detecting HLA Alleles
• HLA-B*5701 Correlations
• HLA-B*5701 Correlations
• Clinical Utility³
• Problems
• If HSR Symptoms are Present⁴
• If HSR Symptoms are Present⁴
• Recommendations for Physicians⁵
• Recommendations for Physicians⁵
• Information for Patients⁵
• Information for Patients⁵
• HLA-B*5701 Genotyping
• References
• Questions?