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What the FDA Relabeling of Abacavir Means for You and Your Patient



HLA-B Antigens and Alleles

Slide 7

November 2008

The Class I HLA proteins (including HLA-B) present peptides to CD8+ T lymphocytes. This may elicit an immune response. HLA-B is a single gene, but generates many protein antigens. However, more than 500 allelic variants are identified by molecular methods. Not all these allelic variants cause a change in the amino acid sequence of the HLA-B antigen, and approximately 50 HLA-B protein antigens encoded by the HLA-B allelic variants and these are identified serologically.

HLA-B Antigens and Alleles

 


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