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What the FDA Relabeling of Abacavir Means for You and Your Patient



Abacavir HSR and HLA Gene

Slide 6

November 2008

Abacavir hypersensitivity reaction is significantly more common in patients with the specific human leukocyte antigen (HLA) allele, HLAB*5701.

The HLA genes are located on the short arm of chromosome 6, and these genes encode for cell surface-expressed protein.

Class I are expressed on most nucleated cells. These are encoded by HLA-A, HLA-B, and HLA-C genes. Class II are found on antigen-presenting cells. These are encoded by HLA-DR, HLA-DQ, and HLA-DP genes.

Abacavir HSR and HLA Gene

 


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