What the FDA Relabeling of Abacavir Means for You and Your Patient
Abacavir HSR and HLA Gene
November 2008
Abacavir hypersensitivity reaction is significantly more common in patients with the specific human leukocyte antigen (HLA) allele, HLAB*5701.
The HLA genes are located on the short arm of chromosome 6, and these genes encode for cell surface-expressed protein.
Class I are expressed on most nucleated cells. These are encoded by HLA-A, HLA-B, and HLA-C genes. Class II are found on antigen-presenting cells. These are encoded by HLA-DR, HLA-DQ, and HLA-DP genes.
Abacavir HSR and HLA Gene |
Jump to section:
- Introduction
- Highly Active Antiretroviral Therapy
- Abacavir
- FDA Caution and Relabeling
- Abacavir Hypersensitivity
- Abacavir HSR and HLA Gene
- HLA-B Antigens and Alleles
- Naming Conventions - HLA-B*5701
- Chromosome 6
- Detecting HLA Alleles
- HLA-B*5701 Correlations
- HLA-B*5701 Correlations
- Clinical Utility3
- Problems
- If HSR Symptoms are Present4
- If HSR Symptoms are Present4
- Recommendations for Physicians5
- Recommendations for Physicians5
- Information for Patients5
- Information for Patients5
- HLA-B*5701 Genotyping
- References
- Questions?
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