What the FDA Relabeling of Abacavir Means for You and Your Patient
Abacavir Hypersensitivity
November 2008
Abacavir hypersensitivity reaction (HSR) is a serious, sometimes fatal, multi-organ syndrome. It is characterized by at least 2 or more of the clinical signs listed here, including fever, rash, gastrointestinal symptoms, respiratory symptoms or other constitutional symptoms such as fever, malaise, or fatigue.
Abacavir Hypersensitivity |
Jump to section:
- Introduction
- Highly Active Antiretroviral Therapy
- Abacavir
- FDA Caution and Relabeling
- Abacavir Hypersensitivity
- Abacavir HSR and HLA Gene
- HLA-B Antigens and Alleles
- Naming Conventions - HLA-B*5701
- Chromosome 6
- Detecting HLA Alleles
- HLA-B*5701 Correlations
- HLA-B*5701 Correlations
- Clinical Utility3
- Problems
- If HSR Symptoms are Present4
- If HSR Symptoms are Present4
- Recommendations for Physicians5
- Recommendations for Physicians5
- Information for Patients5
- Information for Patients5
- HLA-B*5701 Genotyping
- References
- Questions?
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