What the FDA Relabeling of Abacavir Means for You and Your Patient

Problems

November 2008

There are problems in that these may not actually be related to HLA-B*5701. Some minor or moderate symptoms may be due to other causes. Furthermore, not all assays are 100% specific. Other non-5701 alleles that are rare are sometimes reported in only a single individual, but may be detected by the assays. High-resolution bidirectional DNA sequencing is the most accurate test, but it’s also the most expensive test as well.

< Previous Slide

Problems

Next Slide >

 

Jump to section:

• Introduction
• Highly Active Antiretroviral Therapy
• Abacavir
• FDA Caution and Relabeling
• Abacavir Hypersensitivity
• Abacavir HSR and HLA Gene
• HLA-B Antigens and Alleles
• Naming Conventions - HLA-B*5701
• Chromosome 6
• Detecting HLA Alleles
• HLA-B*5701 Correlations
• HLA-B*5701 Correlations
• Clinical Utility³
• Problems
• If HSR Symptoms are Present⁴
• If HSR Symptoms are Present⁴
• Recommendations for Physicians⁵
• Recommendations for Physicians⁵
• Information for Patients⁵
• Information for Patients⁵
• HLA-B*5701 Genotyping
• References
• Questions?