Preanalytic Variables in Special Coagulation Testing

Scope of the Problem

October 2008

In the Mayo Clinic Special Coagulation Laboratory we wanted to investigate how often we encountered clotted specimens. As in any large laboratory it is important to understand the scope of the problem in order to be able to institute continuous improvement processes and then to be able to measure outcomes of changes in processes.

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Scope of the Problem

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Jump to section:

• Introduction
• Variables Affecting Test Results
• Preanalytic Variables Affecting Coagulation Testing
• Special Coagulation Test Algorithms
• Case History
• Preprocedure Coagulation Tests
• PT and aPTT Diagram
• Normal Hematocrit and High Hematocrit
• Preprocedure Coagulation Tests
• Case Conclusion
• Case Example
• Repeat Testing With Fresh Sample
• Intrinsic and Extrinsic Diagram
• Clotted Specimen: Definition of Clotted Specimen
• Significance of Clotted Specimen
• Significance of Clotted Specimen
• Preanalytic Factors Affecting Testing Results: Clotted Specimen
• Scope of the Problem
• Event Capture Tool
• Clotted Specimens as a Percentage of Test Volume
• Clotted Specimens 2007
• Clinical Laboratory Standards Institute
• Rejection of Specimen: Impact
• Causes of Clotted Specimen
• Steps Towards Reducing Clotted Specimens
• Conclusion
• Questions?