Preanalytic Variables in Special Coagulation Testing
Clinical Implications
Repeat Testing With Fresh Sample
October 2008
When we repeated his Factor VIII activity using a fresh sample, the Factor VIII was noted then to be normal. A detailed clinical evaluation revealed that his post dental extraction bleeding was felt to be due to consumption of excessive amounts of ibuprofen which he was taking for pain due to the dental extraction. Ibuprofen induces a platelet dysfunction.
Presents of clot formation in the specimen tube had resulted in a consumption of Factor VII resulting in a misdiagnosis of mild hemophilia A. In addition to such consumption, Factor VIII and Factor V are particularly sensitive to the freeze-thaw effect and may sometimes result in a loss of 10-20% activity.
Repeat Testing With Fresh Sample |
Jump to section:
- Introduction
- Variables Affecting Test Results
- Preanalytic Variables Affecting Coagulation Testing
- Special Coagulation Test Algorithms
- Case History
- Preprocedure Coagulation Tests
- PT and aPTT Diagram
- Normal Hematocrit and High Hematocrit
- Preprocedure Coagulation Tests
- Case Conclusion
- Case Example
- Repeat Testing With Fresh Sample
- Intrinsic and Extrinsic Diagram
- Clotted Specimen: Definition of Clotted Specimen
- Significance of Clotted Specimen
- Significance of Clotted Specimen
- Preanalytic Factors Affecting Testing Results: Clotted Specimen
- Scope of the Problem
- Event Capture Tool
- Clotted Specimens as a Percentage of Test Volume
- Clotted Specimens 2007
- Clinical Laboratory Standards Institute
- Rejection of Specimen: Impact
- Causes of Clotted Specimen
- Steps Towards Reducing Clotted Specimens
- Conclusion
- Questions?
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