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Preanalytic Variables in Special Coagulation Testing

Clinical Implications

Repeat Testing With Fresh Sample

Slide 12

October 2008

When we repeated his Factor VIII activity using a fresh sample, the Factor VIII was noted then to be normal. A detailed clinical evaluation revealed that his post dental extraction bleeding was felt to be due to consumption of excessive amounts of ibuprofen which he was taking for pain due to the dental extraction. Ibuprofen induces a platelet dysfunction.

Presents of clot formation in the specimen tube had resulted in a consumption of Factor VII resulting in a misdiagnosis of mild hemophilia A. In addition to such consumption, Factor VIII and Factor V are particularly sensitive to the freeze-thaw effect and may sometimes result in a loss of 10-20% activity.

Repeat Testing With Fresh Sample


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