Preanalytic Variables in Special Coagulation Testing
Clinical Implications
Case Example
October 2008
The next case is one of a 45 year-old male referred to our hemophilia center for evaluation of diagnosis of mild congenital hemophilia. He had undergone a dental extraction and had more then expected hemorrhage lasting for about a week.
He was tested locally, where von Willebrand factor antigen and ristocetin co-factor activity when noted to be normal; however, Factor VIII was mildly reduced. He brought in his outside medical records and next to the Factor VII results there was an asterisk indicating that a clot was noted in the specimen tube.
Case Example |
Jump to section:
- Introduction
- Variables Affecting Test Results
- Preanalytic Variables Affecting Coagulation Testing
- Special Coagulation Test Algorithms
- Case History
- Preprocedure Coagulation Tests
- PT and aPTT Diagram
- Normal Hematocrit and High Hematocrit
- Preprocedure Coagulation Tests
- Case Conclusion
- Case Example
- Repeat Testing With Fresh Sample
- Intrinsic and Extrinsic Diagram
- Clotted Specimen: Definition of Clotted Specimen
- Significance of Clotted Specimen
- Significance of Clotted Specimen
- Preanalytic Factors Affecting Testing Results: Clotted Specimen
- Scope of the Problem
- Event Capture Tool
- Clotted Specimens as a Percentage of Test Volume
- Clotted Specimens 2007
- Clinical Laboratory Standards Institute
- Rejection of Specimen: Impact
- Causes of Clotted Specimen
- Steps Towards Reducing Clotted Specimens
- Conclusion
- Questions?
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