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Preanalytic Variables in Special Coagulation Testing

Clinical Implications

Case Conclusion

Slide 10

October 2008

To get an accurate result based on published guidelines, the volume of citrate anticoagulant was reduced to 0.25 percent to accommodate the lower volume of plasma. The assays were repeated and indeed were near-normal or normal.

In essence, this patient had an artifactual prolongation of the PT and aPTT due to increased hematocrit. This is not a commonly recognized phenomenon, patient with disease such as cyanotic congenital heart disease and polycythemia rubra vera should be flagged so that specimens can be collected in tubes with adjusted citrate concentration.

Case Conclusion


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