Preanalytic Variables in Special Coagulation Testing
Clinical Implications
Case Conclusion
October 2008
To get an accurate result based on published guidelines, the volume of citrate anticoagulant was reduced to 0.25 percent to accommodate the lower volume of plasma. The assays were repeated and indeed were near-normal or normal.
In essence, this patient had an artifactual prolongation of the PT and aPTT due to increased hematocrit. This is not a commonly recognized phenomenon, patient with disease such as cyanotic congenital heart disease and polycythemia rubra vera should be flagged so that specimens can be collected in tubes with adjusted citrate concentration.
Case Conclusion |
Jump to section:
- Introduction
- Variables Affecting Test Results
- Preanalytic Variables Affecting Coagulation Testing
- Special Coagulation Test Algorithms
- Case History
- Preprocedure Coagulation Tests
- PT and aPTT Diagram
- Normal Hematocrit and High Hematocrit
- Preprocedure Coagulation Tests
- Case Conclusion
- Case Example
- Repeat Testing With Fresh Sample
- Intrinsic and Extrinsic Diagram
- Clotted Specimen: Definition of Clotted Specimen
- Significance of Clotted Specimen
- Significance of Clotted Specimen
- Preanalytic Factors Affecting Testing Results: Clotted Specimen
- Scope of the Problem
- Event Capture Tool
- Clotted Specimens as a Percentage of Test Volume
- Clotted Specimens 2007
- Clinical Laboratory Standards Institute
- Rejection of Specimen: Impact
- Causes of Clotted Specimen
- Steps Towards Reducing Clotted Specimens
- Conclusion
- Questions?
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