Chronic Lymphocytic Leukemia

Introduction

October 2008

Welcome to Mayo Medical Laboratories' Hot Topics. These presentations provide short discussions of current topics and may be helpful to you in your practice.

Our speaker for this program is Dr. Curtis Hanson, from the Division of Hematopathology at Mayo Clinic. Dr. Hanson will be discussing recent changes in the detection and diagnosis of chronic lymphocytic leukemia (CLL). This is the first of two presentations. Part 2 reviews the laboratory’s role in risk stratification for CLL.

Introduction

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Jump to section:

• Goals Today
• CLL, MBL, and SLL Overview
• CLL: Evolution of Diagnostic Criteria
• Chronic B-Cell Lymphoproliferative Disorders: Prototypic Immunophenotype
• CLL: Dim sIg, dim CD20, CD5+ & CD23+
• "Copycat": MCL with CD5+/partial CD23+
• "Copycat": LPL with CD5+/CD23-
• Diagnosis of MBL & SLL: IWCLL
• Diagnostic Criteria: CLL, MBL, and SLL
• Diagnostic Criteria: CLL, MBL, and SLL
• Identification of MBL
• How will MBL be Recognized in Routine Clinical Practice?
• How is MBL Recognized in Routine Clinical Practice?
• Diagnostic Criteria: MBL in Clinical Practice
• MBL: Prevalence and Progression
• MBL: Summary
• Familial CLL
• MBL Case: Clinical History
• MBL Case: Peripheral Blood Immunophenotype
• MBL Case: Bone Marrow Biopsy
• Diagnosis Diagram
• CLL and Minimal Residual Disease (MRD)
• CLL and Minimal Residual Disease (MRD)
• CLL and Minimal Residual Disease (MRD)
• CLL MRD Case: Clinical History
• CLL MRD Case: Clinical History
• CLL MRD Case: Bone Marrow Biopsy
• CLL MRD Case: Bone Marrow Biopsy
• CLL MRD Case: PB Flow
• CLL MRD Case: BM Flow
• Goals Today
• Questions?