Chronic Lymphocytic Leukemia
New Approaches for a Common Disease
Diagnosis of MBL & SLL: IWCLL
October 2008
In addition to redefining CLL the IWCLL also redefined the diagnosis of MBL as well as SLL. MBL is now recognized as a disease entity and is defined as those cases that have a B-cell count of less than 5,000 and having the absence of lymphadenopathy or organomegaly which would be characteristic of SLL. It is important to note that there are similar expressions of genetic risk factors in MBL cases as compared to early stage CLL. SLL is defined as those cases with lymphadenopathy or organomegaly and having a B-cell count of less than 5,000.
Diagnosis of MBL & SLL: IWCLL |
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- Introduction
- Goals Today
- CLL, MBL, and SLL Overview
- CLL: Evolution of Diagnostic Criteria
- Chronic B-Cell Lymphoproliferative Disorders: Prototypic Immunophenotype
- CLL: Dim sIg, dim CD20, CD5+ & CD23+
- "Copycat": MCL with CD5+/partial CD23+
- "Copycat": LPL with CD5+/CD23-
- Diagnosis of MBL & SLL: IWCLL
- Diagnostic Criteria: CLL, MBL, and SLL
- Diagnostic Criteria: CLL, MBL, and SLL
- Identification of MBL
- How will MBL be Recognized in Routine Clinical Practice?
- How is MBL Recognized in Routine Clinical Practice?
- Diagnostic Criteria: MBL in Clinical Practice
- MBL: Prevalence and Progression
- MBL: Summary
- Familial CLL
- MBL Case: Clinical History
- MBL Case: Peripheral Blood Immunophenotype
- MBL Case: Bone Marrow Biopsy
- Diagnosis Diagram
- CLL and Minimal Residual Disease (MRD)
- CLL and Minimal Residual Disease (MRD)
- CLL and Minimal Residual Disease (MRD)
- CLL MRD Case: Clinical History
- CLL MRD Case: Clinical History
- CLL MRD Case: Bone Marrow Biopsy
- CLL MRD Case: Bone Marrow Biopsy
- CLL MRD Case: PB Flow
- CLL MRD Case: BM Flow
- Goals Today
- Questions?
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