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Chronic Lymphocytic Leukemia

New Approaches for a Common Disease

Chronic B-Cell Lymphoproliferative Disorders: Prototypic Immunophenotype

Slide 5

October 2008

This table highlights the prototypic immunophenotypes that are found in the various B-cell lymphoproliferative disorders. Now I don’t want to go through this entire table with you but I do want to point out two things.

First of all, in CLL and SLL the classic immunophenotype is that of dim surface immunoglobulin, dim CD20, and expression of CD5 and CD23. Although this precise phenotype is not found in classic cases of other lymphoproliferative disorders, please note that similar phenotypes can be identified in some cases of lymphoplasmacytic leukemia and occasional cases of Splenic marginal zone lymphoma. As well, you should note that exceptions to the prototypic CLL phenotype can be found in some cases of CLL.

Prototypic Immunophenotype


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