Chronic Lymphocytic Leukemia

CLL, MBL, and SLL Overview

October 2008

To start off with I want to point out that there are three terms that have been used to describe an overlapping group of diseases. CLL, MBL and also Small Lymphocytic Lymphoma (SLL). All three of these have many common features and are closely related from a biological perspective. We know that these diseases have a similar morphologic appearance in peripheral blood, bone marrow and lymph nodes. We know that they have a similar immunophenotype and that they have common and similar genetic factors that can be detected. The separation of these entities is rather arbitrary and is in part related to patients’ sensitivities and how the term leukemia is applied to them. Regardless we must be sure to remember that these are not three separate and unrelated processes.

< Previous Slide

CLL, MBL, and SLL Overview

Next Slide >

 

Jump to section:

• Introduction
• Goals Today
• CLL, MBL, and SLL Overview
• CLL: Evolution of Diagnostic Criteria
• Chronic B-Cell Lymphoproliferative Disorders: Prototypic Immunophenotype
• CLL: Dim sIg, dim CD20, CD5+ & CD23+
• "Copycat": MCL with CD5+/partial CD23+
• "Copycat": LPL with CD5+/CD23-
• Diagnosis of MBL & SLL: IWCLL
• Diagnostic Criteria: CLL, MBL, and SLL
• Diagnostic Criteria: CLL, MBL, and SLL
• Identification of MBL
• How will MBL be Recognized in Routine Clinical Practice?
• How is MBL Recognized in Routine Clinical Practice?
• Diagnostic Criteria: MBL in Clinical Practice
• MBL: Prevalence and Progression
• MBL: Summary
• Familial CLL
• MBL Case: Clinical History
• MBL Case: Peripheral Blood Immunophenotype
• MBL Case: Bone Marrow Biopsy
• Diagnosis Diagram
• CLL and Minimal Residual Disease (MRD)
• CLL and Minimal Residual Disease (MRD)
• CLL and Minimal Residual Disease (MRD)
• CLL MRD Case: Clinical History
• CLL MRD Case: Clinical History
• CLL MRD Case: Bone Marrow Biopsy
• CLL MRD Case: Bone Marrow Biopsy
• CLL MRD Case: PB Flow
• CLL MRD Case: BM Flow
• Goals Today
• Questions?