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Chronic Lymphocytic Leukemia

New Approaches for a Common Disease

CLL, MBL, and SLL Overview

Slide 3

October 2008

To start off with I want to point out that there are three terms that have been used to describe an overlapping group of diseases. CLL, MBL and also Small Lymphocytic Lymphoma (SLL). All three of these have many common features and are closely related from a biological perspective. We know that these diseases have a similar morphologic appearance in peripheral blood, bone marrow and lymph nodes. We know that they have a similar immunophenotype and that they have common and similar genetic factors that can be detected. The separation of these entities is rather arbitrary and is in part related to patients’ sensitivities and how the term leukemia is applied to them. Regardless we must be sure to remember that these are not three separate and unrelated processes.

CLL, MBL, and SLL Overview


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