Chronic Lymphocytic Leukemia

CLL and Minimal Residual Disease (MRD)

October 2008

I want to finish this session by briefly talking about CLL and MRD. MRD eradication is goal of current therapies. But questions certainly exist:

Does absence of MRD improve overall survival?
Does MRD detection predict early relapse?

These questions and others have not been definitively answered. But without a doubt, laboratories are now being asked to detect MRD in CLL patients.

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Minimal Residual Disease (MRD)

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Jump to section:

• Introduction
• Goals Today
• CLL, MBL, and SLL Overview
• CLL: Evolution of Diagnostic Criteria
• Chronic B-Cell Lymphoproliferative Disorders: Prototypic Immunophenotype
• CLL: Dim sIg, dim CD20, CD5+ & CD23+
• "Copycat": MCL with CD5+/partial CD23+
• "Copycat": LPL with CD5+/CD23-
• Diagnosis of MBL & SLL: IWCLL
• Diagnostic Criteria: CLL, MBL, and SLL
• Diagnostic Criteria: CLL, MBL, and SLL
• Identification of MBL
• How will MBL be Recognized in Routine Clinical Practice?
• How is MBL Recognized in Routine Clinical Practice?
• Diagnostic Criteria: MBL in Clinical Practice
• MBL: Prevalence and Progression
• MBL: Summary
• Familial CLL
• MBL Case: Clinical History
• MBL Case: Peripheral Blood Immunophenotype
• MBL Case: Bone Marrow Biopsy
• Diagnosis Diagram
• CLL and Minimal Residual Disease (MRD)
• CLL and Minimal Residual Disease (MRD)
• CLL and Minimal Residual Disease (MRD)
• CLL MRD Case: Clinical History
• CLL MRD Case: Clinical History
• CLL MRD Case: Bone Marrow Biopsy
• CLL MRD Case: Bone Marrow Biopsy
• CLL MRD Case: PB Flow
• CLL MRD Case: BM Flow
• Goals Today
• Questions?