Chronic Lymphocytic Leukemia
New Approaches for a Common Disease
Diagnosis Diagram
October 2008
This cartoon outlines the sequence of events that one follows in reaching a diagnosis in these patients. First of all in the peripheral blood, the CBC and differential count, together with the immunophenotype, are the principal components needed to reach a diagnostic decision. Occasionally, a bone marrow specimen may be helpful but is certainly not required in examination of these patients. Once a diagnosis is reached, classification to CLL, MBL, or other B-cell lymphoproliferative disorders may then be accomplished.
Diagnosis Diagram |
Jump to section:
- Introduction
- Goals Today
- CLL, MBL, and SLL Overview
- CLL: Evolution of Diagnostic Criteria
- Chronic B-Cell Lymphoproliferative Disorders: Prototypic Immunophenotype
- CLL: Dim sIg, dim CD20, CD5+ & CD23+
- "Copycat": MCL with CD5+/partial CD23+
- "Copycat": LPL with CD5+/CD23-
- Diagnosis of MBL & SLL: IWCLL
- Diagnostic Criteria: CLL, MBL, and SLL
- Diagnostic Criteria: CLL, MBL, and SLL
- Identification of MBL
- How will MBL be Recognized in Routine Clinical Practice?
- How is MBL Recognized in Routine Clinical Practice?
- Diagnostic Criteria: MBL in Clinical Practice
- MBL: Prevalence and Progression
- MBL: Summary
- Familial CLL
- MBL Case: Clinical History
- MBL Case: Peripheral Blood Immunophenotype
- MBL Case: Bone Marrow Biopsy
- Diagnosis Diagram
- CLL and Minimal Residual Disease (MRD)
- CLL and Minimal Residual Disease (MRD)
- CLL and Minimal Residual Disease (MRD)
- CLL MRD Case: Clinical History
- CLL MRD Case: Clinical History
- CLL MRD Case: Bone Marrow Biopsy
- CLL MRD Case: Bone Marrow Biopsy
- CLL MRD Case: PB Flow
- CLL MRD Case: BM Flow
- Goals Today
- Questions?
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