Chronic Lymphocytic Leukemia
New Approaches for a Common Disease
Familial CLL
October 2008
The concept of familial CLL has recently emerged. It is now recognized that families with known CLL patients have an increased risk of having MBL or CLL identified within their own kindred. Anywhere from 12%-18% of CLL patients will have an extended family member with CLL or some other type of lymphoproliferative disorder. The precise genetic factors within familial CLL remain undefined and are uncertain.
Familial CLL |
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- Introduction
- Goals Today
- CLL, MBL, and SLL Overview
- CLL: Evolution of Diagnostic Criteria
- Chronic B-Cell Lymphoproliferative Disorders: Prototypic Immunophenotype
- CLL: Dim sIg, dim CD20, CD5+ & CD23+
- "Copycat": MCL with CD5+/partial CD23+
- "Copycat": LPL with CD5+/CD23-
- Diagnosis of MBL & SLL: IWCLL
- Diagnostic Criteria: CLL, MBL, and SLL
- Diagnostic Criteria: CLL, MBL, and SLL
- Identification of MBL
- How will MBL be Recognized in Routine Clinical Practice?
- How is MBL Recognized in Routine Clinical Practice?
- Diagnostic Criteria: MBL in Clinical Practice
- MBL: Prevalence and Progression
- MBL: Summary
- Familial CLL
- MBL Case: Clinical History
- MBL Case: Peripheral Blood Immunophenotype
- MBL Case: Bone Marrow Biopsy
- Diagnosis Diagram
- CLL and Minimal Residual Disease (MRD)
- CLL and Minimal Residual Disease (MRD)
- CLL and Minimal Residual Disease (MRD)
- CLL MRD Case: Clinical History
- CLL MRD Case: Clinical History
- CLL MRD Case: Bone Marrow Biopsy
- CLL MRD Case: Bone Marrow Biopsy
- CLL MRD Case: PB Flow
- CLL MRD Case: BM Flow
- Goals Today
- Questions?
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