Chronic Lymphocytic Leukemia

How will MBL be Recognized in Routine Clinical Practice?

October 2008

In clinical practice, MBL will most commonly be identified when a lymphocytosis is found via CBC screening. I frequently hear questions as to what limits actually define a lymphocytosis. I feel very strongly that a lymphocytosis is defined as those cases having an ALC above3, 000. I think that this has been confirmed by various laboratories who have done thorough normal value studies.

In addition, if one looks at the quantitative lymphocyte subsets that are broadly published, the sum of T-cells, B-cells, and NK-cells would certainly suggest that a lymphocyte value of 3,000 is close to being accurate. The historic number of 5,000 being the upper limit for an ALC should not be used in today’s clinical environment.

< Previous Slide

MBL Recognized in Clinical Practice?

Next Slide >

 

Jump to section:

• Introduction
• Goals Today
• CLL, MBL, and SLL Overview
• CLL: Evolution of Diagnostic Criteria
• Chronic B-Cell Lymphoproliferative Disorders: Prototypic Immunophenotype
• CLL: Dim sIg, dim CD20, CD5+ & CD23+
• "Copycat": MCL with CD5+/partial CD23+
• "Copycat": LPL with CD5+/CD23-
• Diagnosis of MBL & SLL: IWCLL
• Diagnostic Criteria: CLL, MBL, and SLL
• Diagnostic Criteria: CLL, MBL, and SLL
• Identification of MBL
• How will MBL be Recognized in Routine Clinical Practice?
• How is MBL Recognized in Routine Clinical Practice?
• Diagnostic Criteria: MBL in Clinical Practice
• MBL: Prevalence and Progression
• MBL: Summary
• Familial CLL
• MBL Case: Clinical History
• MBL Case: Peripheral Blood Immunophenotype
• MBL Case: Bone Marrow Biopsy
• Diagnosis Diagram
• CLL and Minimal Residual Disease (MRD)
• CLL and Minimal Residual Disease (MRD)
• CLL and Minimal Residual Disease (MRD)
• CLL MRD Case: Clinical History
• CLL MRD Case: Clinical History
• CLL MRD Case: Bone Marrow Biopsy
• CLL MRD Case: Bone Marrow Biopsy
• CLL MRD Case: PB Flow
• CLL MRD Case: BM Flow
• Goals Today
• Questions?