Laboratory Testing for Hepatitis A and E

Patient Case

September 2008

In our individual of this case, she did not have a history of Hepatitis A vaccinations in the past, so the presence of the total Hepatitis A antibody reflects past infection. Based on the history that she is foreign-born and potentially comes from a Hepatitis A endemic area, she probably acquired this infection in the remote past and has lifelong immunity based on this past infection.

In healthy individuals without a history of Hepatitis A vaccination, presence of the Hepatitis A total antibody indicates most likely Hepatitis A IgG antibodies and this is a reflection on past Hepatitis A infections. For those with a history of Hepatitis A vaccination, this result could be due to past infection or vaccine immunity since we do not routinely test for past infection prior to vaccination.

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Jump to section:

• Introduction
• Patient Case
• Geographic Distribution of Hepatitis A Virus Infection
• Hepatitis A Epidemiology
• Hepatitis A Virus Infection Typical Serologic Course
• Hepatitis A Diagnosis
• Assay Methods for HAV Serologic Markers
• Patient Case
• Interpretation of HAV Serologic Marker Test Results
• Patient Case
• Incidence of Acute Hepatitis A by Year
• Incidence of Acute Hepatitis A by Age
• Trends in Epidemiologic Characteristics
• Incidence of Acute Hepatitis A by Race/Ethnicity
• Geographic Distribution of Hepatitis E
• Hepatitis E Epidemiology
• Hepatitis E Virus Infection
• Hepatitis E Diagnosis
• Summary Hepatitis A
• Summary Hepatitis E
• Questions?
• Disclosure