Antibodies Against Citrullinated Peptides
A Role in the Diagnosis of Rheumatoid Arthritis
Diagnostic Performance of Anti-Citrulline Antibodies
September 2008
After the discovery of these antibodies, various studies were performed to determine if they would be an improvement over Rheumatoid factor as a diagnostic marker for Rheumatoid Arthritis. The initial studies done using indirect immunofluorescence indicated that the antibodies lacked sensitivity in comparison to Rheumatoid factor generally being around 40-50%. However, the specificity of these antibodies was a clear improvement, generally being above 95% in most studies.
Diagnostic Performance |
Jump to section:
- Introduction
- Introduction to Connective Tissue Diseases
- Clinical Symptoms of Rheumatoid Arthritis
- Epidemiologic Features of Rheumatoid Arthritis
- Diagnostic Criteria for Rheumatoid Arthritis
- Utility of Rheumatoid Factor
- Discovery of Anti-Citrulline Antibodies
- Enzymatic Process of Citrullination
- Diagnostic Performance of Anti-Citrulline Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Sensitivity and Specificity Comparison Anti-CCP and RF
- Diagnostic Algorithm for CTDs
- Summary
- Questions?
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