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Antibodies Against Citrullinated Peptides

A Role in the Diagnosis of Rheumatoid Arthritis



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Diagnostic Performance of Anti-Citrulline Antibodies

Slide 9

September 2008

After the discovery of these antibodies, various studies were performed to determine if they would be an improvement over Rheumatoid factor as a diagnostic marker for Rheumatoid Arthritis. The initial studies done using indirect immunofluorescence indicated that the antibodies lacked sensitivity in comparison to Rheumatoid factor generally being around 40-50%. However, the specificity of these antibodies was a clear improvement, generally being above 95% in most studies.

Diagnostic Performance

 


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