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Antibodies Against Citrullinated Peptides

A Role in the Diagnosis of Rheumatoid Arthritis



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Enzymatic Process of Citrullination

Slide 8

September 2008

Citrullination is an enzymatic process that results in a post-translational modification of arginine residues found in protein molecules. This process is mediated by peptidyl arginine deiminase (PAD). In the presence of calcium, a positively charged argentine residue is deiminated by the enzyme, ultimately releasing ammonia and forming a neutral amino acid referred to as citrulline. It has been demonstrated by numerous groups that the antibodies originally characterized as anti-perinuclear factor, anti-keratin antibodies and anti-sa are all specific to the citrullinated form of a variety of proteins.

Enzymatic Process of Citrullination

 


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