Antibodies Against Citrullinated Peptides
A Role in the Diagnosis of Rheumatoid Arthritis
Discovery of Anti-Citrulline Antibodies
September 2008
As part of this investigation, several groups independently identified a nodal antibody distinct from Rheumatoid factor. This antibody was originally characterized by indirect immunofluorescence using a variety of tissue substrates. One group named their finding anti-perinuclear factor (APF) because the antibody bound to perinuclear granules in human mucosal cells.
Another group named their finding anti-keratin antibodies (AKAs) due to the demonstration that the antibody bound to epithelial cells. Ultimately, it was demonstrated that both antibodies recognized the same target antigen which was a citrullinated form of filaggrin.
A third discovery was that of anti-Sa which bound to placental or Rheumatoid Arthritis pannus tissue. The target antigen of this antibody was discovered to be citrullinated vimentin.
Discovery of Anti-Citrulline Antibodies |
Jump to section:
- Introduction
- Introduction to Connective Tissue Diseases
- Clinical Symptoms of Rheumatoid Arthritis
- Epidemiologic Features of Rheumatoid Arthritis
- Diagnostic Criteria for Rheumatoid Arthritis
- Utility of Rheumatoid Factor
- Discovery of Anti-Citrulline Antibodies
- Enzymatic Process of Citrullination
- Diagnostic Performance of Anti-Citrulline Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Sensitivity and Specificity Comparison Anti-CCP and RF
- Diagnostic Algorithm for CTDs
- Summary
- Questions?
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