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Antibodies Against Citrullinated Peptides

A Role in the Diagnosis of Rheumatoid Arthritis


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Discovery of Anti-Citrulline Antibodies

Slide 7

September 2008

As part of this investigation, several groups independently identified a nodal antibody distinct from Rheumatoid factor. This antibody was originally characterized by indirect immunofluorescence using a variety of tissue substrates. One group named their finding anti-perinuclear factor (APF) because the antibody bound to perinuclear granules in human mucosal cells.

Another group named their finding anti-keratin antibodies (AKAs) due to the demonstration that the antibody bound to epithelial cells. Ultimately, it was demonstrated that both antibodies recognized the same target antigen which was a citrullinated form of filaggrin.

A third discovery was that of anti-Sa which bound to placental or Rheumatoid Arthritis pannus tissue. The target antigen of this antibody was discovered to be citrullinated vimentin.

Discovery of Anti-Citrulline Antibodies


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