Antibodies Against Citrullinated Peptides
A Role in the Diagnosis of Rheumatoid Arthritis
Diagnostic Criteria for Rheumatoid Arthritis
September 2008
The American College of Rheumatology has established a set of Diagnostic Criteria for Rheumatoid Arthritis. These criteria focus heavily on clinical symptoms. The criteria include morning stiffness that lasts longer than 1 hour, and arthritis of 3 or more joints, particularly the hand joints, that is accompanied by inflammation and swelling.
In particular, Symmetric arthritis is an important indicator of Rheumatoid Arthritis. The presence of nodules is also an indication of the disease as are radiographic changes that indicate the presence of erosions and boney decalcification.
The only laboratory test that is currently part of the criteria is Rheumatoid factor (RF). I have included anticyclic citrullinated peptide (anti-CCP) antibodies on the list on this slide, although it is not part of the official diagnostic criteria. It is possible that it may be included at some point in the future, although many clinicians are using it now as a replacement for Rheumatoid factor.
Diagnostic Criteria |
Jump to section:
- Introduction
- Introduction to Connective Tissue Diseases
- Clinical Symptoms of Rheumatoid Arthritis
- Epidemiologic Features of Rheumatoid Arthritis
- Diagnostic Criteria for Rheumatoid Arthritis
- Utility of Rheumatoid Factor
- Discovery of Anti-Citrulline Antibodies
- Enzymatic Process of Citrullination
- Diagnostic Performance of Anti-Citrulline Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Sensitivity and Specificity Comparison Anti-CCP and RF
- Diagnostic Algorithm for CTDs
- Summary
- Questions?
External
link
PDF
document
Excel
document
Word
document