Antibodies Against Citrullinated Peptides
A Role in the Diagnosis of Rheumatoid Arthritis
Clinical Symptoms of Rheumatoid Arthritis
September 2008
As I just stated, Rheumatoid Arthritis is a systemic disease. In most individuals, the disease begins as articular manifestations generally as a polyarthritis. This process begins with inflammation within the synovial joint. Ultimately, without adequate treatment the disease may progress to erosion and destruction of the cartilage and bone within the joint.
In some pts, the disease progresses beyond the joint. Some of the more common extra-articular manifestations include the development of nodules, osteoporosis, and vasculitis. Some individuals may develop rheumatoid lung disease and cardiac disease as well.
Clinical Symptoms of Rheumatoid Arthritis |
Jump to section:
- Introduction
- Introduction to Connective Tissue Diseases
- Clinical Symptoms of Rheumatoid Arthritis
- Epidemiologic Features of Rheumatoid Arthritis
- Diagnostic Criteria for Rheumatoid Arthritis
- Utility of Rheumatoid Factor
- Discovery of Anti-Citrulline Antibodies
- Enzymatic Process of Citrullination
- Diagnostic Performance of Anti-Citrulline Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Sensitivity and Specificity Comparison Anti-CCP and RF
- Diagnostic Algorithm for CTDs
- Summary
- Questions?
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