Antibodies Against Citrullinated Peptides
A Role in the Diagnosis of Rheumatoid Arthritis
Introduction to Connective Tissue Diseases
September 2008
Rheumatoid Arthritis is an inflammatory disease characterized by an autoimmune etiology. It is classified as a connective tissue disease, or also known as systemic rheumatic disease. It is a chronic disease with patients requiring lifelong monitoring and treatment following diagnosis. Although most people are aware of the joint destruction that accompanies Rheumatoid Arthritis, we also need to be aware that this disease is systemic with the potential to involve a variety of organ systems. Rheumatoid Arthritis is only one of several connective tissues diseases which include lupus, Sjögren syndrome, and scleroderma among others. It can be a challenge to distinguish between these diseases as pts, especially those early in the disease, may present with relatively similar clinical symptoms.
Introduction to Connective Tissue Diseases |
Jump to section:
- Introduction
- Introduction to Connective Tissue Diseases
- Clinical Symptoms of Rheumatoid Arthritis
- Epidemiologic Features of Rheumatoid Arthritis
- Diagnostic Criteria for Rheumatoid Arthritis
- Utility of Rheumatoid Factor
- Discovery of Anti-Citrulline Antibodies
- Enzymatic Process of Citrullination
- Diagnostic Performance of Anti-Citrulline Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Sensitivity and Specificity Comparison Anti-CCP and RF
- Diagnostic Algorithm for CTDs
- Summary
- Questions?
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