Antibodies Against Citrullinated Peptides
A Role in the Diagnosis of Rheumatoid Arthritis
Summary
September 2008
In summary, the anti-CCP antibody test is useful in establishing the diagnosis of Rheumatoid Arthritis. It has similar sensitivity to Rheumatoid factor, but significantly improved specificity. As with all antibody markers, the result of the anti-CCP antibody test must be interpreted in conjunction with other information, including the clinical presentation of the pt and results from other diagnostic testing such as the ANA, discreet antibodies and inflammatory markers.
Summary |
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- Introduction
- Introduction to Connective Tissue Diseases
- Clinical Symptoms of Rheumatoid Arthritis
- Epidemiologic Features of Rheumatoid Arthritis
- Diagnostic Criteria for Rheumatoid Arthritis
- Utility of Rheumatoid Factor
- Discovery of Anti-Citrulline Antibodies
- Enzymatic Process of Citrullination
- Diagnostic Performance of Anti-Citrulline Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Sensitivity and Specificity Comparison Anti-CCP and RF
- Diagnostic Algorithm for CTDs
- Summary
- Questions?
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